主な原著論文・総説・解説




1. Nakamura S, Kurata R, Tonozuka T, Funane K, Park EY, Miyazaki T, Bacteroidota polysaccharide utilization system for branched dextran exopolysaccharides from lactic acid bacteria., J Biol Chem. 2023; 299(7):104885. doi: 10.1016/j.jbc.2023.104885. 
2. Miyazaki T, Tanaka H, Nakamura S, Dohra H, Funane K, Identification and Characterization of Dextran α-1,2-Debranching Enzyme from
Microbacterium dextranolyticum., J Appl Glycosci. 2023; 70(1): 15-24.
3. 舟根和美, 越智幸三, 鈴木龍一郎, 北村進一, 日野志朗, 環状イソマルトオリゴ糖類の生産と利用開発, 応用糖質科学; 2022; 12(4):216-223.
4.Nakamura S, Nihira T, Kurata R, Nakai H, Funane K, Park EY, Miyazaki T, Structure of a bacterial α-1,2-glucosidase defines mechanisms of hydrolysis and substrate specificity in GH65 family hydrolases., J Biol Chem. 2021; 297(6):101366.  doi:org/10.1016/j.jbc.2021.101366.
5. Mizushima D, Miyazaki T, Shiwa Y, Kimura K, Suzuki S, Fujita N, Yoshikawa H, Kimura A, Kitamura S, Hara H, Funane K, A novel intracellular dextranase derived from Paenibacillus sp. 598K with an ability to degrade cycloisomaltooligosaccharides., Appl Microbiol Biotechnol. 2019; 103(16): 6581-6592. doi: 10.1007/s00253-019-09965-y.
6. Funane K, Tanaka Y, Hosaka T, Murakami K, Miyazaki T, Shiwa Y, Gibu S, Inaoka T, Kasahara K, Fujita N, Yoshikawa H, Hiraga Y, Ochi K, Combined Drug Resistance Mutations Substantially Enhance Enzyme Production in Paenibacillus agaridevorans. J Bacteriol. 2018; 200(17): pii: e00188-18. doi: 10.1128/JB.00188-18.
7. 舟根和美, 水島大貴, 宮崎剛亜, 儀部茂八, 鏡朋和, 鈴木志保, 北村進一, 原博, アンカー型環状イソマルトメガロ糖の生産と用途. New Food Industry(株式会社 食品資材研究会)2017; 59(5): 1-10.
8. Fujimoto Z, Suzuki N, Kishine N, Ichinose H, Momma M, Kimura A, Funane K, Carbohydrate-binding architecture of the multi-modular α-1,6-glucosyltransferase from Paenibacillus sp. 598K, which produces α-1,6-glucosyl-α-glucosaccharides from starch. Biochem J. 2017; 474(16): 2763-2778. doi: 10.1042/BCJ20170152.
9. Fujimoto Z, Kishine N, Suzuki N, Suzuki R, Mizushima D, Momma M, Kimura K, Funane K., Isomaltooligosaccharide-binding structure of Paenibacillus sp. 598K cycloisomaltooligosaccharide glucanotransferase. Biosci Rep. 2017; 37(2): pii: BSR20170253. doi: 10.1042/BSR20170253. 
10. Ichinose H, Suzuki R, Miyazaki T, Kimura K, Momma M, Suzuki N, Fujimoto Z, Kimura A, Funane K, Paenibacillus sp. 598K 6-α-glucosyltransferase is essential for cycloisomaltooligosaccharide synthesis from α-(1 → 4)-glucan. Appl Microbiol Biotechnol. 2017; 101(10): 4115-4128. doi: 10.1007/s00253-017-8174-z.
11. Matsunaga K, Setoguchi S, Shimono K, Kamesawa H, Nakamura T, Funane K, Identification of Turbid Compounds Generated in Sugarcane Vinegar., J Appl Glycosci. 2016; 63(1): 23-26. doi.org/10.5458/jag.jag.JAG-2015_020.
12. Suzuki R, Suzuki N, Fujimoto Z, Momma M, Kimura K, Kitamura S, Kimura A, Funane K., Molecular engineering of cycloisomaltooligosaccharide glucanotransferase from Bacillus circulans T-3040: structural determinants for the reaction product size and reactivity. Biochem J. 2015; 467(2): 259-270. doi: 10.1042/BJ20140860.
13. Saito K, Nakamura T, Kobayashi I, Ohnishi-Kameyama M, Ichinose H, Kimura K, Funane K, Xylan-mediated aggregation of Lactobacillus brevis and its relationship with the surface properties and mucin-mediated aggregation of the bacteria. Biosci Biotechnol Biochem. 2014; 78(12): 2120-2127. doi: 10.1080/09168451.2014.948375.
14. Suzuki N, Fujimoto Z, Kim YM, Momma M, Kishine N, Suzuki R, Suzuki S, Kitamura S, Kobayashi M, Kimura A, Funane K, Structural elucidation of the cyclization mechanism of α-1,6-glucan by Bacillus circulans T-3040 cycloisomaltooligosaccharide glucanotransferase. J Biol Chem. 2014; 289(17): 12040-12051. doi: 10.1074/jbc.M114.547992.
15. Funane K, Ichinose H, Araki M, Suzuki R, Kimura K, Fujimoto Z, Kobayashi M, Kimura A., Evidence for cycloisomaltooligosaccharide production from starch by Bacillus circulans T-3040. Appl Microbiol Biotechnol. 2014; 98(9): 3947-3954. doi: 10.1007/s00253-014-5515-z.
16. Suzuki S, Yukiyama T, Ishikawa A, Yuguchi Y, Funane K, Kitamura S., Conformation and physical properties of cycloisomaltooligosaccharides in aqueous solution. Carbohydr Polym. 2014; 99: 432-437. doi: 10.1016/j.carbpol.2013.07.089.
17. 舟根和美, 小林麻里子, 大脇静香, 鈴木龍一郎, 一ノ瀬仁美, 環状イソマルトオリゴ糖・メガロ糖の生産. New Food Industry(株式会社 食品資材研究会)2014; 56: 25-32.
18. Suzuki N, Kim YM, Momma M, Fujimoto Z, Kobayashi M, Kimura A, Funane K., Crystallization and preliminary X-ray crystallographic analysis of cycloisomaltooligosaccharide glucanotransferase from Bacillus circulans T-3040. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013; 69(Pt 8): 946-949. doi: 10.1107/S174430911301991X.
19. Kubo Y, Inaoka T, Hachiya T, Miyake M, Hase S, Nakagawa R, Hasegawa H, Funane K, Sakakibara Y, Kimura K., Development of a rifampicin-resistant Bacillus subtilis strain for natto-fermentation showing enhanced exoenzyme production. J Biosci Bioeng. 2013; 115(6): 654-657. doi: 10.1016/j.jbiosc.2012.12.012.
20. 久保雄司, 齋藤勝一, ダニエル・ホルヴェック, 舟根和美, 中川力夫, 木村啓太郎, 菌体外分解酵素が増強された納豆菌rpoB変異株による黒大豆納豆の製造. 日本食品科学工学会誌, 2013; 60: 577-581.
21. Kim YM, Yamamoto E, Kang MS, Nakai H, Saburi W, Okuyama M, Mori H, Funane K, Momma M, Fujimoto Z, Kobayashi M, Kim D, Kimura A., Bacteroides thetaiotaomicron VPI-5482 glycoside hydrolase family 66 homolog catalyzes dextranolytic and cyclization reactions. FEBS J. 2012; 279(17): 3185-3191. doi: 10.1111/j.1742-4658.2012.08698.x.
22. Suzuki R, Terasawa K, Kimura K, Fujimoto Z, Momma M, Kobayashi M, Kimura A, Funane K., Biochemical characterization of a novel cycloisomaltooligosaccharide glucanotransferase from Paenibacillus sp. 598K. Biochim Biophys Acta. 2012; 1824(7): 919-24. doi: 10.1016/j.bbapap.2012.04.001.
23. Kim YM, Kiso Y, Muraki T, Kang MS, Nakai H, Saburi W, Lang W, Kang HK, Okuyama M, Mori H, Suzuki R, Funane K, Suzuki N, Momma M, Fujimoto Z, Oguma T, Kobayashi M, Kim D, Kimura A., Novel dextranase catalyzing cycloisomaltooligosaccharide formation and identification of catalytic amino acids and their functions using chemical rescue approach. J Biol Chem. 2012; 287(24): 19927-19935. doi: 10.1074/jbc.M111.339036.
24. Suzuki N, Kim YM, Fujimoto Z, Momma M, Okuyama M, Mori H, Funane K, Kimura A., Structural elucidation of dextran degradation mechanism by Streptococcus mutans dextranase belonging to glycoside hydrolase family 66. J Biol Chem. 2012; 287(24): 19916-19926. doi: 10.1074/jbc.M112.342444.
25. Kawabata Y, Kimura K, Funane K., Extracellular production of cycloisomaltooligosaccharide glucanotransferase and cyclodextran by a protease-deficient Bacillus subtilis host-vector system. Appl Microbiol Biotechnol. 2012; 93(5): 1877-1884. doi: 10.1007/s00253-011-3671-y. 
26. Suzuki N, Kim YM, Fujimoto Z, Momma M, Kang HK, Funane K, Okuyama M, Mori H, Kimura A., Crystallization and preliminary crystallographic analysis of dextranase from Streptococcus mutans., Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011; 67(Pt 12): 1542-1544. doi: 10.1107/S1744309111038425.
27. Kim YM, Shimizu R, Nakai H, Mori H, Okuyama M, Kang MS, Fujimoto Z, Funane K, Kim D, Kimura A., Truncation of N- and C-terminal regions of Streptococcus mutans dextranase enhances catalytic activity. Appl Microbiol Biotechnol. 2011; 91(2): 329-339. doi: 10.1007/s00253-011-3201-y.
28. 舟根和美, 川端康之, 鈴木龍一郎, 藤本瑞, 北岡本光, 小林幹彦, 環状イソマルトオリゴ糖グルカノトランスフェラーゼの分子解析とBacillus circulans T-3040株における環状イソマルトオリゴ糖の生合成経路の発見, 応用糖質科学, 2011; 1: 179-185.
29. Funane K, Kawabata Y, Suzuki R, Kim YM, Kang HK, Suzuki N, Fujimoto Z, Kimura A, Kobayashi M., Deletion analysis of regions at the C-terminal part of cycloisomaltooligosaccharide glucanotransferase from Bacillus circulans T-3040. Biochim Biophys Acta. 2011; 1814(3): 428-434. doi: 10.1016/j.bbapap.2010.12.009. 
30. Konishi T, Ohnishi-Kameyama M, Funane K, Miyazaki Y, Konishi T, Ishii T., An arginyl residue in rice UDP-arabinopyranose mutase is required for catalytic activity and autoglycosylation. Carbohydr Res. 2010; 345(6): 787-791. doi: 10.1016/j.carres.2010.01.008.
31. 舟根和美, 微生物酵素による高機能オリゴ糖の生産と応用(サイクロデキストラン合成酵素の構造とメカニズムの解析、および構造・利用技術開発), 食糧(農研機構 食品総合研究所)2010; 48: 45-61.
32. 舟根和美, 実用化されたオリゴ糖・サイクロデキストラン,化学と生物 (日本農芸化学会)2010; 48(3): 152-153.
33. 舟根和美, 新規オリゴ糖素材サイクロデキストランの生産と応用, FFIジャーナル, 2008; 213: 1000-1008.
34. Funane K, Terasawa K, Mizuno Y, Ono H, Gibu S, Tokashiki T, Kawabata Y, Kim YM, Kimura A, Kobayashi M., Isolation of Bacillus and Paenibacillus bacterial strains that produce large molecules of cyclic isomaltooligosaccharides. Biosci Biotechnol Biochem. 2008; 72(12): 3277-3280.
35. Funane K, Terasawa K, Mizuno Y, Ono H, Miyagi T, Gibu S, Tokashiki T, Kawabata Y, Kim YM, Kimura A, Kobayashi M., A novel cyclic isomaltooligosaccharide (cycloisomaltodecaose, CI-10) produced by Bacillus circulans T-3040 displays remarkable inclusion ability compared with cyclodextrins. J Biotechnol. 2007; 130(2): 188-192.
36. 川端康之, 舟根和美, 北尾悟, 大腸菌組換え型環状イソマルトオリゴ糖合成酵素(CITase)の調製と反応特性., 食品・臨床栄養, 2007; 2: 35-40.
37. 渡嘉敷唯章, 金城健作, 舟根和美, 伊藤汎, 黒糖中の環状イソマルトオリゴ糖の存在について, J. Appl. Glycosci., 2007; 54: 27-30.
38. 舟根和美, 抗う蝕性環状イソマルトオリゴ糖(サイクロデキストラン)の生産技術開発;食品工業, 2006; 49: 29-37.
39. Yamamoto T, Terasawa K, Kim YM, Kimura A, Kitamura Y, Kobayashi M, Funane K., Identification of catalytic amino acids of cyclodextran glucanotransferase from Bacillus circulans T-3040. Biosci Biotechnol Biochem. 2006; 70(8): 1947-1953.
40. 川端康之, 北尾悟, 舟根和美, 渡嘉敷唯章, 儀部茂八, 宮城貞夫, グアニジン変異およびストレプトマイシン耐性変異による環状イソマルトオリゴ糖合成酵素(CITase)生産菌Bacillus circulans の育種, 食品・臨床栄養, 2006; 1: 43-48.
41. Funane K, Ishii T, Ono H, Kobayashi M., Changes in linkage pattern of glucan products induced by substitution of Lys residues in the dextransucrase. FEBS Lett. 2005; 579(21): 4739-4745.
42. Funane K, Ishii T, Terasawa K, Yamamoto T, Kobayashi M., Construction of chimeric glucansucrases for analyzing substrate-binding regions that affect the structure of glucan products. Biosci Biotechnol Biochem. 2004; 68(9): 1912-1920.
43. Nakai S, Ogawa M, Nakamura S, Dou J, Funane K, A computer-aided strategy for structure-function relation study of food proteins using unsupervised data mining., Int. J. Food Properties, 2003; 6: 25-47.
44. Funane K, Matsuo T, Gibu S, Tokashiki T, Kobayash Mi, Purification and characterization of dextran and dextransucrase produced by a newly isolated strain of Leuconostoc sp. S-51., J. Appl. Glycosci., 2003; 50(2): 290-291.
45. 舟根和美, 進化の過程で捨てられてしまった?多糖合成酵素―新規デキストランスクラーゼ様遺伝子の発見, 化学と生物, 2001; 39: 571-572.
46. Funane K, Ishii T, Matsushita M, Hori K, Mizuno K, Takahara H, Kitamura Y, Kobayashi M., Water-soluble and water-insoluble glucans produced by Escherichia coli recombinant dextransucrases from Leuconostoc mesenteroides NRRL B-512F. Carbohydr Res. 2001; 334(1): 19-25.
47. Mizuno K, Kobayashi E, Tachibana M, Kawasaki T, Fujimura T, Funane K, Kobayashi M, Baba T., Characterization of an isoform of rice starch branching enzyme, RBE4, in developing seeds. Plant Cell Physiol. 2001: 42(4): 349-357.
48. Funane K, Mizuno K, Takahara H, Kobayashi M., Gene encoding a dextransucrase-like protein in Leuconostoc mesenteroides NRRL B-512F. Biosci Biotechnol Biochem. 2000; 64(1): 29-38.
49. 舟根和美, Leuconostoc mesenteroides 由来のデキストラン合成酵素の構造と機能の解明, J. Appl. Glycosci., 2000; 47: 105-115.
50. Funane K, Mizuno K, Terasawa K, Kitamura Y, Baba T, Kobayashi M, Reaction of a rice branching enzyme, RBE1, on various kinds of starches analyzed by high-performance anion exchange chromatography., J. Appl. Glycosci., 1999; 46(4): 453-457.
51. Funane K, Libessart N, Stewart D, Michishita T, Preiss J., Analysis of essential histidine residues of maize branching enzymes by chemical modification and site-directed mutagenesis. J Protein Chem. 1998; 17(7): 579-590.
52. Funane K, Ookura T, Kobayashi M., Glucan binding regions of dextransucrase from Leuconostoc mesenteroides NRRL B-512F. Biosci Biotechnol Biochem. 1998; 62(1): 123-127.
53. 舟根和美,デキストランの生合成-化学修飾を用いたデキストラン合成酵素の触媒部位の検索-,食糧(農水省 食品総合研究所), 1997; 36: 105-125.
54. Kobayashi M, Chiba Y, Funane K, Ohya S, Kato Y., Mold Pectinase Modified with Dialdehyde Derivatives of Dextran and Cellulose. Biosci Biotechnol Biochem. 1996; 60(5): 794-797. doi: 10.1271/bbb.60.794.
55. Kobayashi M, Funane K, Oguma T., Inhibition of dextran and mutan synthesis by cycloisomaltooligosaccharides. Biosci Biotechnol Biochem. 1995; 59(10): 1861-1865.
56. Funane K, Yamada M, Shiraiwa M, Takahara H, Yamamoto N, Ichishima E, Kobayashi M., Aggregated form of dextransucrases from Leuconostoc mesenteroides NRRL B-512F and its constitutive mutant. Biosci Biotechnol Biochem. 1995; 59(5): 776-780.
57. Funane K, Shiraiwa M, Hashimoto K, Ichishima E, Kobayashi M., An active-site peptide containing the second essential carboxyl group of dextransucrase from Leuconostoc mesenteroides by chemical modifications. Biochemistry. 1993; 32(49): 13696-13702. 

工業所有権

1. 舟根和美,堀端大路,坂井真知
水難溶性物質を含有する水溶液の製造方法,特願2020-17614 (2020/2/5),特開2021-123554 (2021.8.30).
2. 北村進一,鈴木志保,中野歩美,舟根和美,原博,
可溶化剤,特願2015-71049 (2015/3/31), 特開2016-190803(2016/11/10), 特許第6551921号 (2019/7/12).
3. 北村進一, 鈴木志保, 舟根和美,
α-1,3-分岐シクロデキストランの使用方法, 特願2010-293595 (2010/12/28), 特開2012-14521 (2012/7/26), 特許第5688798号 (2015/2/6).
4. 舟根和美, 北岡本光, 宮城貞夫, 儀部茂八,
デキストラングルカナーゼ, 特願2010-246426 (2010/11/2), 特開2012-095606 (2012/5/24), 特許第5751661号 (2015/5/29).
5. 舟根和美, 北岡本光, 川端康之, 宮城貞夫, 儀部茂八,
サイクロデキストランの製造方法およびサイクロデキストラン合成酵素の製造方法, 特願2007-276158 (2007/10/24), 特開2008-167744 (2008/7/24), 特許第5481716号 (2014/2/28).
6. 舟根和美, 寺澤和恵, 宮城赳, 宮城貞夫,
好アルカリ性サイクロデキストラン合成酵素遺伝子を含有するDNA, 組み換え体DNA、および好アルカリ性サイクロデキストラン合成酵素の製造法, 特願2006-008318 (2006/1/17), 特開2007-189905 (2007/8/2), 特許題4815219号 (2011/9/2).
7. 舟根和美,水野康子,宮城赳,宮城貞夫,
サイクロデキストラン高生産微生物とこれを用いたサイクロデキストランの製造法, 特願2004-003704 (2004/1/9), 特開2005-192510 (2005/7/21), 特許第4395380号 (2009/10/23).
8. 舟根和美, 寺澤和恵, 宮城赳, 宮城貞夫, 小林幹彦,
高分子サイクロデキストラン、その製造法及びそれに用いる微生物, 特願2002-337748 (2002/11/21), 特開2004-166624 (2004/6/17), 特許第4122208号(2008/5/9).
9. 舟根和美, 小林幹彦, 北村義明,
改変デキストランスクラーゼ、その遺伝子組み換え体、グルカンの製造法, 特願2001-307067 (2001/10/3), 特開2003-111590 (2003/4/15), 特許第3709435号 (2005/8/19). 

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