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　　　　　　　　　　Publications
　　　　　　　　　　Department of Pharmacology
　　　　　　　　　　　 　Interdisciplinary Graduate School of Medicine and Engineering
　　　　　　　　　　 　　University of Yamanashi

Detailed data are avairable at Researcher ID , Researchmap, Researchgate, Linkedin, Publons and Orcid Pages.

2022
[58] Danjo Y, Shigetomi E, Hirayama Y, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J, Koizumi S.
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice. JEM, in press

[57] Parajuli B, Shinozaki Y, Shigetomi E, Koizumi S.
Transplantation of Human Induced Pluripotent Stem Cell-derived Microglia in Immunocompetent Mice Brain via Non-invasive Transnasal Route. JOVE, 2022

[56] Danjo Y^#, Shinozaki Y^#, Natsubori A, Kashiwagi K, Kanji F Tanaka, Koizumi S. The Mlc1 promoter directs Muller cell-specific gene expression in the retina. TVST ,2022, 11: 25.

2021
[55] Hamada K^#, Shinozaki Y^#, Namekata K, Matsumoto M, Ohno N, Segawa T, Kashiwagi K, Harada T, Koizumi S. Loss of P2Y₁ receptor triggers glaucoma-like pathology in mice.
Br J Pharmacol. 2021, 178: 4552-4571.

[54] Parajuli B, Saito H, Shinozaki Y, Miwa H, Yoneda S, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima K, Koizumi S.
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
GLIA, 2021, 69: 2332-2348.

[53] Tanaka M, Parajuli B, Shigetomi E, Nagatomo H, Shinozaki Y, Hirayama Y, Saito K, Kubota Y, Danjo Y, Lee JH, Kim SK, Nabekura J, Koizumi S.
Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
GLIA, 2021, 69: 2546-2558.

[49-2] Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Sugita K, Aihara M, Koizumi S.
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus
JCI Insight, 2021, 6: e135391.

[52] Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada T.
Development of a label-free ATP imaging sensor for analyzing spatiotemporal patterns of ATP resease from biological tissues.
Sens Act B: Chemical, 2021, 335, 129686

[51] Shinozaki Y, Koizumi S.
Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma (Review)
Journal of Pharmacological Sciences,2021, 145: 262-267.

2020
[50] Shinozaki Y, Koizumi S.
Potential role of glial dysfunction in pathogenesis of glaucoma (Japanese)
Folia Pharmacol. Jpn. 2020, 155:87-92.

2019

[49] Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Sugita K, Aihara M, Koizumi S.
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus
bioRxiv → accepted to JCI Insight

[48] Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M.
Intermitttent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia
Sci Rep 20019, 9: 10069.

[47] Shinozaki Y, Danjo Y, Koizumi S
Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration
Journal of Neurochemistry,2019, 151: 64-78.


2018
[46] Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A and Hwang GW
Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures.
J. Toxicol. Sci. 2019, 44: 471-479.

[45] Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, Takeda A, Ngoc Le HP, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S.
Anti-depressesant fluoxetine reveals its therapeutic effect via astrocytes.
EBioMedicine 2018, 32: 72-83
Press release (in Japanese)


[44] ^#Takeda A, ^#Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J and Koizumi S. (^#co-first authors)
Microglia mediate non-cell-autonomous cell death of retinal ganglion cells
GLIA 2018, 66: 2366-2384.

[43] Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M and Koizumi S.
The Oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium.
Sci Rep 2018, 8: 5699.


2017
[42] Shinozaki Y, Kashiwagi K, Namakata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T and Koizumi S.
Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy
JCI Insight 2017, 2(19): e93456
Press release (Japanese)
日本経済新聞
QLifePro医療ニュース
Japan MDC医療・社会ニュース
医療情報サイトm3
ワークスブリッジ
医薬品・医療機器産業企業ニュース
大学コム
大学ニュース
山梨経済ニュースtwitter

[41] Ihara T, Mitsui T, Nakamura Y, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M and Koizumi S.
The circadian expression of Piezo1, TRPV4, Coonexin26 and VNUT, associated with expression levels of the clock genes in mouse primary cultured urothelial cells.
Neurourology and Urodynamics,2018, 37: 942-951

[40] Katoh M, Wu B, Ngyen HB, Thai TQ, Yamasaki R, Lu H, Rietsh AM, Zorlu MM, Shinozaki Y, Saitoh Y, Saitoh S, Satoh K, Ikenaka K, Koizumi S, Ransohoff RM and Ohno N
Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.
Sci Rep 2017, 7: 4942.

[39] Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF and Koizumi S
Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y1 receptor downregulation
Cell Reports 2017, 19: 1151-1164
Press release (japanese)
日刊工業新聞
日本経済新聞
毎日新聞(printed)
信濃毎日新聞
山梨日日新聞
ライブドアニュース
Academicationニュース
マイナビニュース
グノシー
日本の研究.com
excite news
Open gate news
Scoopnest
医薬ニュース.com

[38] Ihara T, Mitsui T, Nakamura Y, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Andersson KL, Nakao A, Takeda M and Koizumi S
Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26 and VNUT in an Ex Vivo Mouse Bladder Mucosa.
PLoS One 2017, 12: e0168234 (IF₂₀₁₆ = 3.1)


2016

[37] Nakagomi H, Yoshiyama M, Mochizuki T, Miyamoto T, Komatsu R, Imura Y, Morizawa Y, Hiasa M, Miyaji T, Kira S, Araki I, Fujishita K, Shibata K, Shigetomi E, Shinozaki Y, Ichikawa R, Uneyama H, Iwatsuki K, Nomura M, Groat WC, Moriyama Y, Takaeda M and Koizumi S
Urothelial ATP exocytosis: regulation of bladder compliance in the urine strage phase.
Scientific reports 2016, 6: 29761.(IF₂₀₁₅ = 5.2)

[36] Ihara T, Mitsui T, Kira S, Miyamoto T, Sawada N, Nakagomi H, Yoshiyama M, Takeda M, Nakamura Y, Nakao A, Shinozaki Y and Koizumi S
The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria
Neurourology and Urodynamics, 2016, in press (IF₂₀₁₅ = 3.13)

[35] Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee H, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S* and Nabekura J*
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain (*co-correspondence)
Journal of Clinical Investigation, 2016, 126: 1983-1997. (IF₂₀₁₅ = 13.26) Picked up in F1000Prime
Press Release
日本経済新聞
毎日新聞
信濃毎日新聞
山梨日日新聞
福井新聞
マイナビニュース
Sciense Portal
医療News
はてなブックマーク
The Science News

[34] Taguchi M*, Shinozaki S*, Kashiwagi K, Shigetomi E, Robaye B and Koizumi S. (*co-first)
Muller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y6 receptor signals
Journal of Neurochemistry, 2016, 136: 741-751. (IF₂₀₁₄ = 4.34)

2014
[33] Y. Shinozaki, M. Nomura, K. Iwatsuki, Y. Moriyama, C. Gachet and S. Koizumi
Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission
Scientific Reports, 2014, 4, 4329 (IF2013 = 5.1)

[32] Y. Shinozaki*, A. Tanaka, N. Kasai, K. Torimitsu, K. Sumitomo
Ligand-induced structural changes in membrane-reconstituted ion channel observed with atomic force microscopy
Appl. Phys. Express. 2014, 7(2), 027001 (IF2013 = 2.6)*corresponding author

2013

[31]Y. Imura, Y. Morizawa, R. Komatsu, K. Shibata, Y. Shinozaki, H. Kasai, K. Moriishi, Y. Moriyama, S. Koizumi
Microglia release ATP by exocytosis
GLIA 2013, 61: 1320-1330 (IF2013 = 5.5)

[30] Y. Noguchi, Y. Shinozaki, K. Fujishita, K. Shibata, Y. Imura, Y. Morizawa, C. Gachet, S. Koizumi (_ equal contribution)
Astrocytes protect neurons against methylmercury via ATP/P2Y1 receptor-mediated pathways in astrocytes
PLoS One, 2013, 8, e57898 (IF2013 = 3.5)

[29] F. Takata, S. Dohgu, A. Yamaguchi, J. Matsumoto, T. Machida, K. Fujishita, K. Shibata, Y. Shinozaki, K. Sato, Y. Kataoka and S. Koizumi
In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.
PLoS One, 2013, 8, e55166 (IF2013 = 3.5)

2012
[28] K. Sumitomo*, A. McAllister, Y. Tamba, Y. Kashimura, A. Tanaka, Y. Shinozaki, and K. Torimistsu
Ca²⁺ ion transport through channels formed by alpha-hemolysin analyzed using a microwell array on a Si substrate
Biosensor and Bioelectronics, 31, 445-450 (IF = 5.64)

2011


[27] Y. Shinozaki*, K. Sumitomo, A. Tanaka, N. Kasai, and K. Torimitsu
Examination of Ion Channel Protein Orientation in Supported Lipid Bilayers
Appl. Phys. Express (APEX), 2011, 4, 107001 (IF = 3.01)

[26] K. Shibata, T. Sugawara, K. Fujishita, Y. Shinozaki, T. Matsukawa, T. Suzuki, and S. Koizumi
The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice
PLoS One, 2011, 6: e23510 (IF2010= 4.4) selected as the top 10% most cited PLoS One article!
　　　　　　　

[25] 篠崎陽一*、住友弘二、河西奈保子、田中あや、鳥光慶一
原子間力顕微鏡を用いた生体分子のトポロジー観察
表面科学 32巻、2011年, 104-109

2010

[24] K. Sumitomo*, Y. Tamba, Y. Shinozaki, K. Torimitsu
Confinement of fluorescent probes in micro-wells on Si substrates by sealing with lipid bilayer
Appl. Phys. Express (APEX), 2010, 3, 107001. (IF = 2.223)

[23] H. Nakashima*, K. Furukawa, Y. Kashimura, K. Sumitomo, Y. Shinozaki, and K. Torimitsu
Pattern formationa and molecular transport of histidine-tagged GFPs using supported lipid bilayers.
Langmuir, 2010, 26(15), 12716-12721 (IF = 3.898).

[22] Y. Shinozaki*, K. SUmitomo, K. Furukawa, H. Miyashita, Y. Tamba, N. Kasai, H. Nakashima, K. Torimitsu
Visualization of membrane protein suspended over nanoscale well.
Appl. Phys. Express (APEX), 2010, 3, 027002. (IF = 2.223) (APEX top pageに掲載、Top 20 Most Downloaded Articlesに選ばれました!）
　　
2009
[21] 篠崎陽一*、住友弘二、津田誠、小泉修一、井上和秀、鳥光慶一：
高速原子間力顕微鏡を用いた受容体の一分子イメージング
日薬理誌(Folia Pharmacol. Jpn.) 134巻, 2号, 68-72, 2009年 (表紙に掲載されました!)

[20] Y. Shinozaki
Direct observation of dynamics in receptor protein by atomic force microscopy
NTT Technical Rev. 7(8)

[19] 篠崎陽一
主役登場　バイオの力を通信に
NTT技術ジャーナル, 21巻, 6号, 40, 2009年

[18] 篠崎陽一
原子間力顕微鏡による受容体タンパク質の動的構造解析
NTT技術ジャーナル, 21巻, 6号, 20-23, 2009年

[17] Y. Shinozaki*, K. Sumitomo, M. Tsuda, S. Koizumi, K. Inoue, K. Torimitsu
Direct observation of ATP-induced conformaitonal changes in single P2X4 receptors
PLoS Biol. 2009, 7(5) e1000103. (IF = 13.5 )　*corresponding author
Press Release: http://www.medicalnewstoday.com/articles/149029.php

[16] K. Sumitomo*, Y. Shinozaki, D. Takagi, H. Nakashima, Y. Kobayashi, K. Torimitsu
AFM observation of membrane proteins suspended over CNT network
Jpn. J. Appl. Phys., 2009, 48: 08JB18.(IF = 1.138)

[15] 河西奈保子、C. S. Ramanujan, 篠崎陽一、住友弘二、J. F. Ryan, 鳥光慶一
受容体タンパク質の一分子観察
化学とマイクロ・ナノシステム研究会誌、2009年、第8巻、第1号、1-6

2008

[14] A. M. Siitonen, K. Sumitomo*, C. S. Ramanujan, Y. Shinozaki, N. Kasai, K. Furukawa, J. F. Ryan, K. Torimitsu
Elasticity of the purple membrane measured by atomic force microscopy
Appl. Surf. Sci. 2008, 254; 7877-7880 (IF = 1.4)

[13] 鳥光慶一、篠崎陽一、河西奈保子、住友弘二
単一分子レベルでのたんぱく質の機能評価
応用物理学会誌、第77巻、第5号、530-533

[12] Y. Shinozaki*, A. M. Siitonen, K. Sumitomo, K. Furukawa, K. Torimitsu
Effect of calcium ions on lipid dynamics analyzed with fast scanning atomic force microscopy
Jpn. J. Appl. Phys. 2008, 47(7): 6164-6167 (IF = 1.2)

[11] T. Suzuki, N. Tamehiro, Y. Sato, T. Kobayashi, A. Ishii-Watanabe, Y. Shinozaki, T. Nishimaki-Mogami, T. Hashimoto, Y. Asakawa, K. Inoue, Y. Ohno, T. Yamanagushi, T. Kawanishi
The novel compounds that activate farnesoid X receptor: the diversity of their effects on gene expression
J. Pharmacol. Sci. 2008, 107(3): 285-294. (IF = 2.4)

2007

[10] S. Koizumi, Y. Shigemoto-Mogami, K. Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B. V. Joshi, K. A. Jacobson, S. Kohsaka, K. Inoue*
UDP acting at P2Y₆ receptors is a mediator of microglial phagocytosis　
Nature, 2007, 446: 1091-1095 (IF = 34.48)

[9] Y. Shinozaki, Y. Sato*, S. Koizumi, Y. Ohno, T. Nagao, K. Inoue
Retinoic acids acting through retinoid receptors protect hipppocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of JNK and p38 mitogen-activated protein
Neuroscience, 2007, 147(1):153-63.(IF = 3.292)

[8] S. Ishida, H. Tanabe, Y. Shinozaki, S. Koyano, H. Kagechika, K. Shudo, S. Ozawa, J. Sawada, Y. Ohno, K. Inoue
How DNA microarray technology contributes to the retinoid evaluations
In "Vitamin A: a new research", Nova Science Publishers, 2007

2006

[7] Y. Shinozaki, S. Koizumi, Y. Ohno, T. Nagao, K. Inoue*
Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes
GLIA, 2006, 54: 606-618 (IF = 5.4, GLIA 2005, 2006の一連の研究成果が日本薬理学会誌2007年9月号の表紙に掲載）

[6] T. Suzuki, T. Nishimaki-Mogami, H. Kawai, T. Kobayashi, Y. Shinozaki, Y. Sato, T. Hashimoto, Y. Asakawa, K. Inoue, Y. Ohno, T. Hayakawa, T. Kawanishi*
Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives.
Phytomedicine 2006, 13: 401-411.

2005

[5] Y. Shinozaki, S. Koizumi, S. Ishida, J.I. Sawada, Y. Ohno, K. Inoue*
Cytoprotection against oxidative stress-induced damage of astrocytes by extracellular ATP via P2Y1 receptors
GLIA 2005, 49: 288-300 (IF = 5.4)

2004

[4] S. Ishida, Y. Shigemoto-Mogami, Y. Shinozaki, H. Kagechika, K. Shudo, S. Ozawa, J. Sawada, Y. Ohno, K. Inoue*
Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and AM80-induced HL-60 cell differentiation revealed by DNA microarray analysis
Biochem. Pharmacol. 2004, 68: 2177-2186.

2002

[3] Y. Shinozaki, N. Fukamiya*, C. Uchiyama, M. Okano, K. Tagahara, K. F. Bastow, K. H. Lee
Multidrug resistance cancer cells susceptibility to cytotoxic taxane diperpenes from Taxus yunnanensis and Taxus chinensis
Bioorg. Med. Chem. Lett. 2002, 12: 2785-2788.

[2] Y. Shinozaki, N. Fukamiya*, M. Okano, T. Nehira, K. Tagahara, S.-X. Zhang, K.-H. Lee
Dantaxusins C and D, two novel taxoids from Taxus yunnanensis
J. Nat. Prod. 2002, 65: 371-374.

2001

[1] Y. Shinozaki, N. Fukamiya*, M. Fukushima, M. Okano, T, Nehira, K. Tagahara, S.-X. Zhang, D.-C. Zhang, K.-H. Lee
Dantaxusins A and B, two new taxoids from Taxus yunnanensis
J. Nat. Prod. 2001, 64: 1073-1076.

Press Release
・Apr 13. 2016: from NIPS
・Apr 13. 2016: from 日本経済新聞

・May 6, 2009: Medical News Today " Scientists See ATP Open The Door"
(http://www.medicalnewstoday.com/articles/149029.php)
・May 6, 2009: ZAMP Bionews " Scientists See ATP Open The Door"
(http://www.bionews.zampbioworld.org/index.php/2009/05/06/22026)
・May 6, 2009: Modern Medicine News " Scientists See ATP Open The Door"
(http://www.modernmedicinenews.com/2009/05/06/scientists-see-atp-open-the-door/)
・2009年5月14日：日刊工業新聞　「ナノレベル観察技術　九州大・NTT ATPの変化解明」
(http://www.nikkan.co.jp/news/six06.html)
・2009年5月25日：日経産業新聞「受容体の動き、連続観察　原子間力顕微鏡を利用　NTT・九大」

Patents
Japanese Patents
・篠崎陽一、柏木賢治、小泉修一 特願2018-115732
「正常眼圧緑内障モデル、及び評価対象薬剤の正常眼圧緑内障予防乃至治療効果の評価方法」
・篠崎陽一、柏木賢治、小泉修一　特開2017-051181
「 緑内障モデル、評価対象薬剤の緑内障予防乃至治療効果の評価方法、及び眼圧調整剤」
・特願2007-204245　タンパク質機能解析装置
・特願2008-216459　生体分子機能解析用基板、生体分子機能解析用試料体および生体分子機能解析方法
・特願2008-296830　膜タンパク質機能測定基板及び膜タンパク質機能測定方法
・特願2008-319944　膜タンパク質の脂質膜内配向評価方法