• Biosensors

    Highly sensitive biomeasurements with small devices

  • Electrochemical microscop

    Mapping of local concentration distribution of chemical substances
    Utilize of closed bipolar electrode array for high spatiotemporal resolution

Welcome to K. Y. Inoue Lab

K. Y. Inoue Group started on August 2020.

We welcome to contact us for laboratory tours at any time
Joint research proposals from researchers and companies are also welcomed

What's new

The first Koshin Research Exchange Seminar with the Analytical Chemistry Laboratory of Shinshu University (Professors Kim and Tatsumi and Associate Professor Takahashi) was held at the University of Yamanashi. The program included a tour of the Center for Instrumental Analysis and provided a valuable opportunity for research exchange.
K. Kubota will give an oral presentation entitled “Elucidation of the Coreactant Electrochemiluminescence Mechanism by In Situ Electron Spin Resonance and Optical Spectroscopy” at the 86th Symposium of the Japan Society for Analytical Chemistry, held at Kurume City Plaza on May 30–31, 2026. M2 students R. Suzuki and Takizawa will present posters entitled “Development of an Electrochemiluminescence Transmission System from a Bipolar Electrode Array Probe for In Vivo Oxygen Imaging” and “Prussian Blue Modification of Electrodes for Hydrogen Peroxide Imaging Using Closed Bipolar Electrodes,” respectively.
An article entitled “Paste-Press Packing Method for Through-Hole Loading to Fabricate Vertical Closed Bipolar Electrode Arrays and Micro-Rods,” with K. Kubota as the first author, was published in ECS Journal of Solid State Science and Technology. The newly developed paste-press packing (PPP) method enables reproducible loading of paste materials into microscale through-holes in thin membranes and provides a simple route to electrode arrays for bipolar electrochemical microscopy and to micro-rods.
K. Kubota has been selected to receive the IEIJ Research Encouragement Award. Congratulations!
From April 1, the faculty and staff will move to the Division of Materials Science (Clean Energy Research Center). We sincerely thank everyone in the Division of Basic Science (Center for Basic Education) for their support and look forward to working with our colleagues in the Clean Energy Research Center.
The graduation ceremony was held. Congratulations to all graduates! Lab members gathered for a light lunch to celebrate, and it was difficult to say goodbye.
At the 93rd Annual Meeting of The Electrochemical Society of Japan, held at the Noda Campus of Tokyo University of Science, K. Kubota presented “Vacuum-Assisted Paste Pressure Filling for Closed Bipolar Electrode Arrays and Surface Modification of the Substrate and Filler,” and D1 student Endo presented “Enhanced Emission and Sensitivity of Bipolar Electrochemical Microscopy Using Tapered Electrode Arrays.” We appreciate the valuable questions and advice received during and after the presentations.
The two-day undergraduate thesis presentation session has concluded. Nagaoka and Aoki, thank you for your hard work. We held a lab lunch on the final day; Aoki will soon be moving away.
The two-day master’s thesis presentation session has concluded. Takei, thank you for your hard work. Please keep going until the final thesis submission.
Uemura from the Institute of Enology and Viticulture gave his undergraduate thesis presentation.
M1 student Takizawa will receive an award for his outstanding poster presentation at the master’s interim presentation session. Congratulations!
The M1 interim presentation session was held. Takizawa and Suzuki, thank you for your hard work. We hope the advice you received will help advance your research.
We held a welcome party for Sakano and a celebration for Lerato after her entrance examination. Everyone ate very well.
Sakano, a third-year student in Applied Chemistry, joined our group.
Lerato Leuta from Lesotho joined our group as a research student. She will conduct collaborative research with Professor Kumagai of Chiba Institute of Technology and Professor Inukai of the Fuel Cell Nanomaterials Center at the University of Yamanashi.
The fall semester has begun. K. Y. Inoue teaches “Basic Analytical Chemistry,” mainly for first-year engineering students, and “Advanced Chemistry Laboratory” for second-year Applied Chemistry students.
M1 student Suzuki received the Outstanding Poster Award at the 43rd Summer School of the Kanto Branch of The Electrochemical Society of Japan. Her presentation, “Development of an Electrochemiluminescence Transmission System from a Bipolar Electrode Array Probe for In Vivo Imaging of Intercellular Substance Dynamics,” investigated the transmission of electrochemiluminescence from a bipolar electrode array through an optical-fiber array for imaging brain chemistry in freely moving rats. The award was featured on the Applied Chemistry website, Faculty of Engineering website, and Faculty of Engineering Instagram.
Our project, “Tank-Mounted Automated Sulfite Sensor for Efficient Wine Production Management and Branding,” was selected by the Inland Japan Innovation Ecosystem (IJIE), one of JST’s regional platform co-creation support programs. The project will be conducted with Assistant Professor Fumie Saito, M2 student Ozawa, and B4 student Uemura of the Institute of Enology and Viticulture.
A management team was formed for our project in the third KSP Deep Tech Studio program. We will work for three months toward commercialization of an automated sulfite sensor for wine production management.
K. Y. Inoue lectured at the seminar “Latest Biosensor Technologies for Digital Health” organized by Johokiko Co., Ltd. Thank you very much to all participants.
The spring semester has begun. K. Y. Inoue teaches the final third of “Basic Chemistry” for first-year engineering students, the first half of “Advanced Analytical Chemistry” for Applied Chemistry graduate students, and the June 17 class of “Advanced Integrated Engineering” for graduate students.
B4 students Nagaoka and Aoki participated as teaching assistants in the Applied Chemistry freshman camp, with K. Y. Inoue as one of the faculty supervisors. Together with students from the Clean Energy course, we spent two enjoyable days at the Yamanashi Prefectural Yatsugatake Youth Outdoor Learning Center and stopped for ice cream at Seisen-Ryo on the way home.
Endo’s award was featured on the Faculty website and department website.
The new academic year has begun.
K. Y. Inoue will lecture at the “Biosensors” seminar organized by Johokiko Co., Ltd. on May 26, 2025. A discounted registration fee is available through the lecturer referral; please contact us if interested.
M2 student Endo’s presentation at the “Life Science and Electrochemistry” symposium of the 92nd Annual Meeting of The Electrochemical Society of Japan was selected for the Outstanding Student Presentation Award. Congratulations!
The graduation and commencement ceremonies were held. Congratulations to B4 students Suzuki and Takizawa and M2 student Endo. We wish them continued success in their next programs.
M2 student Endo, Research Assistant Professor Kubota, and K. Y. Inoue attended the 92nd Annual Meeting of The Electrochemical Society of Japan at the Koganei Campus of Tokyo University of Agriculture and Technology. Endo gave an oral presentation on dopamine detection and two-dimensional imaging using closed bipolar electrodes with a cathodic luminophore, and Kubota presented on electrochemiluminescence transmission through optical fibers for in vivo analysis.
The undergraduate thesis presentations were held over two days. B4 student Suzuki presented “Electrochemiluminescence Transmission through Optical Fibers for In Vivo Imaging Using a Bipolar Electrode Array Probe,” and Takizawa presented “Improvement of Bipolar Electrode Arrays with Reduced Ionic Current through Carbon-Paste Materials and Filling Methods.” We look forward to their continued progress in the master’s program.
The master’s thesis presentations were held on February 4–5. M2 student Endo presented “Two-Dimensional Dopamine Imaging Using Closed Bipolar Electrodes with a Cathodic Luminophore.” We look forward to further progress in her doctoral research.
The final presentation session for the second-year Monozukuri Seminar was held. Kojima and Morimoto presented the results of their two-year project. Although we are sorry to see the course end, we hope the experience will be valuable in the future.
Mari Ishihara joined our group as a research assistant.
The master’s interim presentation session was held on December 21. M1 student Takei presented a poster on the development of bipolar electrochemical microscopy for imaging intercellular lactate transport. We appreciate the many useful comments and questions and wish him success toward his master’s thesis.
We cooked rice sent by Ito and enjoyed it with tonjiru soup. The Yamagata-grown “Tsuyahime” rice was glossy, fluffy, and delicious! (Photo)
K. Y. Inoue attended ACCS 2024 at the Kitakyushu International Conference Center as a member of the International Organizing Committee and gave a presentation entitled “Au Paste as an Electrode Material for Enhanced Electrochemiluminescence and Microrod Fabrication.”
Tomoki Iwama, who completed his degree at Tohoku University in 2022, visited the laboratory for two days to provide experimental guidance.
Laboratory tours for third-year students have begun.
K. Y. Inoue gave a science lecture at a meeting of the Kanto Branch executive committee of The Electrochemical Society of Japan.
M2 student Endo, Research Assistant Professor Kubota, and K. Y. Inoue attended PRiME 2024 in Honolulu. Endo and Kubota presented posters entitled “Au Paste Electrode to Increase the Intensity of Cathodic Electrochemiluminescence” and “Study on the Production Mechanism of Fluorescent Species and Its Application to White LED of NH4-Form Y-Type Zeolite,” respectively. K. Y. Inoue gave an invited lecture entitled “Development of Vertical Closed Bipolar Microelectrode Arrays for Biochemical Imaging.” (Photo)
The fall semester has begun. K. Y. Inoue teaches Basic Analytical Chemistry, the second-year Monozukuri Seminar, and the second-year Chemistry Laboratory course.
K. Y. Inoue received an Encouragement Award under the University of Yamanashi Outstanding Faculty Recognition Program for FY2024.
K. Y. Inoue attended the 73rd Annual Meeting of the Japan Society for Analytical Chemistry at Nagoya Institute of Technology and presented collaborative work with Kobayashi, Ito, Ozawa, and Dr. Saito on sulfite determination using sulfite oxidase for wine-production management.
We participated in the Kanto Branch “Summer School” of The Electrochemical Society of Japan for the first time. Endo and Takei gave excellent presentations, Takizawa introduced the laboratory, and Kubota, Suzuki, and Takizawa served as poster judges. (Photo)
We held a summer eel dinner to celebrate completion of the graduate-school entrance examination. The eel from Akebono was large, tender, and delicious. Let us continue working hard together. (Photo)
An article entitled “Bipolar Electrochemical Sensor with Perylene Diimide-Based Cathodic Luminophore for Dopamine Detection and Imaging,” with Tomoki Iwama as first author and K. Y. Inoue as one of the corresponding authors, was published in Talanta. Using perylene diimide (PDI-CH3) as a cathodic ECL luminophore eliminated the large background observed with the ruthenium-complex system reported previously, enabling more sensitive dopamine detection by bipolar electrochemical microscopy.
The spring semester has begun. K. Y. Inoue teaches the latter third of first-year Basic Chemistry, the second-year Monozukuri Seminar, the second-year Chemistry Laboratory, and the first half of Advanced Analytical Chemistry for graduate students.
We held a cherry-blossom viewing party to welcome new members. Because of the weather, we took a group photo under the campus cherry trees during the day and held a takoyaki party in the laboratory that evening. (Photo)
Yagioka and Yamanaka, members of the second Monozukuri Seminar cohort, received first prize at the Applied Chemistry seminar presentation competition held in January. Their persistent work cultivating slime molds paid off. Congratulations! (Photo)
The new academic year began with Takei joining the group as an M1 student.
M1 student Endo passed the Class A Hazardous Materials Engineer examination. Congratulations on passing this highly competitive examination. Future candidates may be able to receive exam-preparation tips from Research Assistant Professor Kubota, whose trainees have achieved a 92% pass rate.
The University of Yamanashi graduation ceremony was held. Congratulations to Mizukura and Kobayashi. We celebrated with a small laboratory lunch. They will begin careers at companies involved in measurement instruments and food production, respectively. We wish them every success and hope they will visit us again.
New M1 student Taishi Ozawa of the Institute of Enology and Viticulture joined our collaborative project as a research assistant. He will work on biosensors for wine-production management.
Research Assistant Professor Kubota, M2 student Endo, and K. Y. Inoue attended the 91st Annual Meeting of The Electrochemical Society of Japan at Nagoya University. Kubota presented on the relationship between electrochemiluminescence and fluorescence properties of dyes, and Endo presented on Au-paste electrodes for enhancing bipolar electrochemical microscopy signals.
An article entitled “Enhancement of Electrochemiluminescence by Au Paste Electrode for Bipolar Electroanalysis,” authored by Endo, was published in Electrochemistry. The study showed that Au-paste electrodes enhance ECL and provided evidence suggesting a surface-plasmon enhancement effect from Au nanoparticles in the paste.
Endo’s article “Enhancement of Electrochemiluminescence by Au Paste Electrode for Bipolar Electroanalysis” was published online in advance in Electrochemistry.
A collaborative COI Tohoku article entitled “Relationship between Plasma Lipopolysaccharide Concentration and Health Status in Healthy Subjects and Patients with Abnormal Glucose Metabolism in Japan: A Preliminary Cross-Sectional Study,” coauthored by K. Y. Inoue, was published in J. Multidiscip. Res.. The study examines the relationship between plasma endotoxin levels and health status in patients with abnormal glucose metabolism and may support future applications of simple endotoxin sensors.
Third-year Applied Chemistry students Suzuki and Takizawa joined our group.
K. Y. Inoue attended the 14th Asian Conference on Chemical Sensors (ACCS 2023) at the University of Santo Tomas in Manila and gave an oral presentation entitled “Fabrication of Vertical Electrode Array Using Carbon Paste for Bipolar Electrochemical Microscopy.” She also joined the ACCS International Steering Committee.
First-year Applied Chemistry student Morimoto joined our research activities through the My House Plan.
Research Assistant Professor Kubota attended the 69th Annual Meeting of the Polarographic Society of Japan in Goto, Nagasaki, and presented a poster on fabrication methods and electrochemical evaluation of electrode arrays for closed bipolar electrochemical microscopy.
An article entitled “C-Reactive Protein Detection Using an Ion-Sensitive Field-Effect Transistor (ISFET)-Based Aptasensor with a Chemically Modified Gate Surface for Improved Sensitivity,” with Mastura Siti of Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was published in Sensors and Materials. We thank Professor Esashi of Tohoku University for his guidance.
The ”Special Issue on Recent Trends in Electrochemical Biosensing”, for which K. Y. Inoue served as Guest Editor, was published online in Sensors and Materials. Thank you for the many submissions. The open-access issue presents recent advances in biosensing, particularly technologies relevant to digital health.
The fall semester has begun. K. Y. Inoue teaches first-year Basic Chemistry, the first- and second-year Monozukuri Seminar, and the second-year Chemistry Laboratory course.
K. Y. Inoue received an Encouragement Award under the University of Yamanashi Outstanding Faculty Recognition Program for FY2023.
At the 72nd Annual Meeting of the Japan Society for Analytical Chemistry in Kumamoto, M1 student Endo and Research Assistant Professor Kubota presented posters on enhancement of cathodic ECL using Au-paste electrodes and on the emission behavior of ECL species for bipolar electrochemical microscopy, respectively. Endo’s presentation was the first conference presentation by a student from the Inoue Laboratory.
Research Assistant Professor Kubota received the 2022 Encouragement Award for Research on Precious Metals from the TANAKA Memorial Foundation. His project was entitled “Fabrication of Gold Microrods Using a Paste Pressure-Filling Method.” A representative of TANAKA Precious Metals visited the laboratory for the award ceremony. (2022 Encouragement Award for Research on Precious Metals from the TANAKA Memorial Foundation)
Laboratory seminar activities for first-year students began. Together with Kojima and Morimoto of Applied Chemistry, we will develop a lactate sensor for sweat.
K. Y. Inoue received the Research Encouragement Award at the 24th Enzyme Application Symposium of the Amano Enzyme Foundation. The awarded project was entitled “A Highly Sensitive, Compact, and Simple Electrochemical Sensor Using Protease Reactions.”
A photograph of the Chemistry Laboratory course taught by K. Y. Inoue appeared in University of Yamanashi magazine Vine, Vol. 42. Please see page 9 of the issue. M1 student Endo also participates as a teaching assistant in the 2023 spring semester.
We held a welcome party for Ito, Kobayashi, and Mizukura. We had hoped to meet outdoors, but the cold weather moved the event to the faculty room. (Photo) Welcome to our lab!
The spring semester has begun. K. Y. Inoue teaches first-year Basic Chemistry, first-year Basic Analytical Chemistry, the first- and second-year Monozukuri Seminar, the second-year Chemistry Laboratory, and an intensive doctoral course in Functional Measurement Chemistry.
Reo Kani, Chika Suzue, and Riyo Yonemoto, members of last year’s seminar, received an Outstanding Presentation Award at the FY2022 Monozukuri Seminar presentation competition. Congratulations! (Photo)
The new academic year began with Takahiro Ito joining as a research assistant professor. A collaboration with Dr. Fumie Saito of the Institute of Enology and Viticulture also began, and B4 student Momoka Kobayashi joined the project.
Kubota visited Saitama Institute of Technology for three days for collaborative research with Professor Yasushi Hasebe. B3 student Chihiro Takei of the Hasebe Laboratory joined the project.
A collaborative article entitled “Energy-Harvesting and Mass Sensor Performances of Magnetostrictive Cobalt Ferrite–Spattered Fe–Co Alloy Plate,” with Assistant Professor Daiki Kurita of Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was accepted for publication in J. Alloys Compd..
We celebrated graduation with a light laboratory lunch. We look forward to beginning the new academic year with a new team. (Photo)
Naganuma, who graduated in FY2021, stopped by the laboratory while visiting the University of Yamanashi for work.
We held a farewell party for Abe near Kofu Station. We wish him great success at Osaka University. (Photo)
The undergraduate thesis presentations have concluded. The fourth-year students worked very hard, and we celebrated with lunch in the laboratory.
K. Y. Inoue’s essay “Ten Years Behind in My Career” was published in the “Voices of Women Researchers and Students” section of the National Diversity Network website.
An article entitled “Droplet-Free Digital Immunoassay Based on Electrochemiluminescence,” with Kentaro Ito of Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was published in Biosens. Bioelectron. X.
Second-year seminar students presented “Fabrication of a Glucose Sensor and Measurement of Commercial Foods” at the FY2022 Monozukuri Seminar presentation session. They prepared enthusiastically through the year-end holidays and clearly presented the results of their two-year project.
An article entitled “Highly Sensitive Electrochemical Endotoxin Sensor Based on Redox Cycling Using an Interdigitated Array Electrode Device,” with Kentaro Ito of Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was published in Micromachines.
K. Y. Inoue gave an invited lecture on fabrication of high-density closed bipolar electrode arrays for bipolar electrochemical microscopy at the 32nd Annual Meeting of the Materials Research Society of Japan, held in Yokohama on December 5–7.
Collaborative research with Professor Fumio Narita’s group at Tohoku University on a battery-free wireless micro-load sensing system using bending vibration for coronavirus detection was announced in a press release.
K. Y. Inoue received the Outstanding Award of the FY2022 University of Yamanashi Gender Equality Research Award. The award ceremony was featured on the University of Yamanashi website and Faculty of Engineering website.
Third-year Applied Chemistry student Mizukura joined our group.
D2 student Abe of the Ukita Laboratory, Department of Mechanical Engineering received the Outstanding Student Presentation Award at the 68th Annual Meeting of the Polarographic Society of Japan. His presentation was entitled “Relationship between Redox Potentials of Luminophores and Electrochemiluminescence in Bipolar Electrochemical Microscopy.” A photograph is available on the Faculty of Engineering website.
K. Y. Inoue, Kubota, and Abe attended the 68th Annual Meeting of the Polarographic Society of Japan. Kubota and Abe presented posters on enhanced ECL from cathodic luminophores dispersed in conductive paste and on the relationship between luminophore redox potentials and ECL in bipolar electrochemical microscopy, respectively.
An article entitled “High-Sensitivity Amperometric Dual Immunoassay Using Two Cascade Reactions with Signal Amplification of Redox Cycling in Nanoscale Gap,” with Kentaro Ito of Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was published in Analytical Chemistry. It was also selected for a supplementary cover.
The fall semester has begun. K. Y. Inoue teaches first-year Basic Chemistry and the second-year Chemistry Laboratory course.
A refrigerated planetary mill, refrigerated planetary mill LP-M2C (Ito Seisakusho), was installed. It will be used for wet milling of the cathodic ECL luminophore PDI-CH3. Uniformly dispersing fine particles in conductive paste is expected to improve the uniformity and reproducibility of emission from bipolar electrochemical microscopy elements.
K. Y. Inoue received an Encouragement Award under the University of Yamanashi Outstanding Faculty Recognition Program for FY2022.
Kubota received a Ph.D. in Engineering under the supervision of Professor Hideto Sakane in the Department of Applied Chemistry, University of Yamanashi. Congratulations! A photograph of the degree ceremony is available on the degree ceremony. His dissertation was entitled “Formation Mechanism of Fluorescent Species in Calcined Zeolites.”
K. Y. Inoue attended the online 73rd Annual Meeting of the International Society of Electrochemistry on September 12–16 and presented “Bipolar Electrochemical Microscopy for Real-Time Chemical Imaging Using Nanocarbon Paste Microelectrode Array.”
Kubota and K. Y. Inoue attended the hybrid 2022 Fall Meeting of The Electrochemical Society of Japan at Kanagawa University on September 8–9. They presented on conductive-paste filling of micro-through-hole arrays and surface modification of ISFETs for aptasensor applications, respectively. Inoue’s presentation was given in the 71st Chemical Sensor Research Conference session.
Kubota and K. Y. Inoue attended the Photonics Discussion Meeting in Tokushima on September 1–2 and presented on rare-earth-free fluorescent zeolites and on measurement of biological systems using bipolar electrochemical microscopy, respectively.
An article entitled “Highly Sensitive Electrochemical Immunoassay Using Signal Amplification of the Coagulation Cascade,” with Kentaro Ito of Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was published in Analytical Chemistry and selected for a Supplementary Cover. The study demonstrated a highly sensitive immunoassay using coagulation-cascade amplification, extending our previous dual-amplification approach based on the Limulus cascade and redox cycling in a nanogap electrode.
An article entitled “Detection of Virus-Like Particles Using Magnetostrictive Vibration Energy Harvesting,” with Assistant Professor Daiki Kurita of Professor Fumio Narita’s group at Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was published in Sensors and Actuators A: Physical. The work demonstrates sensing and energy harvesting with a new magnetostrictive material and may contribute to autonomous environmental virus-detection systems.
An article entitled “Fabrication of High-Density Vertical Closed Bipolar Electrode Arrays by Carbon Paste Filling Method for Two-Dimensional Chemical Imaging,” with Tomoki Iwama of Tohoku University as first author and K. Y. Inoue as one of the corresponding authors, was published in Analytical Chemistry. The paper describes a method for filling glass microcapillary arrays with carbon paste to fabricate bipolar electrochemical microscopy devices.
An article entitled“Fabrication of High-Density Vertical Closed Bipolar Electrode Arrays by Carbon Paste Filling Method for Two-Dimensional Chemical Imaging”of which K. Y. Inoue is one of a corresponding author is published on Anal. Chem.
Laboratory seminar activities for first-year students have begun. Together with Mr. Yagioka and Ms. Yamanaka from the Department of Applied Chemistry, we will investigate whether slime molds can solve a maze.
K. Kubota's research result was published on Journal of Luminescence.
Inoue will participate in the Fusion Forum at Tokyo Institute of Technology, held on June 23–24, and introduce the FOREST research project “Measurement of Living Systems Using Bipolar Electrochemical Microscopy.” The first day is open to the public.
Inoue gave a lecture entitled “Toward Visualization of Intercellular Signaling Molecules Using Nano-Bipolar Electrode Arrays” at the fifth seminar of the Investigating R&D Committee on Nano-Structure and Interface Formation by Quantum Beams and Biomedical Applications, organized by the Technical Committee on Light and Quantum Devices of the Institute of Electrical Engineers of Japan.
The first-semester courses have begun.

Inoue teaches Basic Chemistry for first-year ME students (Monday, fourth period), Basic Analytical Chemistry for first-year AC students (Tuesday, first period), the Monozukuri Seminar for first- and second-year AC students (Friday, third period), Chemistry Laboratory for second-year EE students (Thursday, third to fifth periods), and the first half of Advanced Analytical Chemistry for master’s students (Thursday, first period).
The new academic year has begun. Ms. Yuri Totsuka, a fourth-year undergraduate from the collaborating Kuwabara Laboratory, has joined our research activities. Ms. Mari Ishihara, an administrative assistant from the collaborating Hajime Sato Laboratory, will also visit us from time to time.
Inoue’s research was featured in No. 2021-3 of “Business Chance Express from the University of Yamanashi!”, published by Yamanashi Chuo Bank.
Inoue participated in a FOREST panel meeting and introduced the research project “Measurement of Living Systems Using Bipolar Electrochemical Microscopy.”
The University of Yamanashi has released its 2021 Online Science and Engineering Course for Female Junior and Senior High School Students and Their Parents. Inoue contributed a 13.5-minute video entitled “Biotechnology: Let’s Make a Biosensor,” featuring first-year seminar students developing glucose biosensors. Please take a look.
Mr. Iwama from Tohoku University is visiting our laboratory for one week to transfer his research. The laboratory is lively with him here.
Mr. Abe, a first-year doctoral student in Mechanical Engineering, has joined our research activities.
Inoue received a FY2021 research grant from the Research Foundation for Opto-Science and Technology.
Our laboratory was featured in Nashidai Researchers Vol. 9.
Mr. Naganuma gave his graduation research presentation. As the laboratory’s first student, he did an excellent job building his research from the ground up. The four laboratory members celebrated with boxed lunches while taking precautions against infection. We also thank the members of Tohoku University for their support.
The CMC Publishing book Enzyme Biotechnology Supporting Near-Future Digital Health: Sensors and Power Generation, which includes Inoue’s chapter “Biosensing and Bioimaging Using Bipolar Electrodes,” has been published.
The 4th COI Academic Exchange Meeting, chaired by Inoue, was held on February 6–7, 2022. Inoue and Mr. Kubota presented posters, and Inoue’s presentation, “Development of Electrochemical Biosensors and Bioimaging Devices for Healthcare,” received an Outstanding Poster Award. A meeting report is available here.
Inoue gave a lecture entitled “Sensor Development for Digital Health and Its Extension to Microscopy for Imaging Intercellular Molecular Transport” at the 28th Academic Salon.
We introduced our research at a seminar of the Yamanashi GLIA Center, exchanged ideas, and toured the facilities. We received many valuable suggestions for applying bipolar electrochemical microscopy to neuroscience.
Researcher Koki Kubota joined our group.
Inoue presented “Dopamine Imaging Using a Bipolar Electrochemical Microscopy System with a Ruthenium Bipyridine Complex and Oxidized Glutathione as Cathodic Luminophores” at the 31st Annual Meeting of the Materials Research Society of Japan at Pacifico Yokohama North, Room G214.
Inoue gave a lecture entitled “Biosensing and Bioimaging Using Electrochemical Sensors” at a lecture meeting of the Kanto Branch of the Chemical Society of Japan.
Inoue’s research project was selected for the JST FOREST Program. The project appears in the list of projects selected in FY2021 and was also featured in the University’s News & Topics.
Ms. Endo, a third-year student in the Department of Applied Chemistry, joined our group.
Our research achievement, “Microscope Elements for Capturing Molecular Motion Developed by Thermal Drawing,” was announced in a press release from the Tohoku University COI Center.

In collaboration with Assistant Professor Guo and colleagues at Tohoku University, Inoue achieved the world’s first mass production of BEM electrode elements using thermal drawing, a process that applies heat and tension to thermoplastic materials to produce fibers with arbitrary cross-sectional designs. This work was conducted in part through the COI Young Researcher Collaboration Fund. The mass-production technology is expected to accelerate further fundamental studies toward biomolecular imaging.
"When dry batteries are connected in series" co-authored by Inoue and Professor Tatsumi of Shinshu University was published in Review of Polarographye as a series "Electroanalytical Chemistry, This is Difficult! Part 8 (Edited by Masahiro Yamamoto)"(Japanese)
An article entitled“Thermally-drawn multi-electrode fibers for bipolar electrochemistry and magnified electrochemical imaging”of which K. Y. Inoue is one of a corresponding author is accepted for publication on Advanced Materials Technologies.
An article entitled“Electrochemical Immunoassay with Dual Signal Amplification for Redox Cycling within a Nanoscale Gap”of which K. Y. Inoue is one of a corresponding author is accepted for publication on ACS Applied Nano Materials.
Ms. Suzue from the Department of Applied Chemistry joined the first-year seminar.
The second semester has been started.
K. Y. Inoue will lecture at the Faculty of Science, University of Hyogo from 3rd period on September 28th to 5th period on 29th September. Following Professor Hiroshi Shiiki's lecture on nanobiosciencef, she will have a lecture on biosensors and bioimaging. Unfortunately it's an online class..
K. Y. Inoue presented research results on "Dopamine imaging using cathodic electrochemiluminescence generated by co-reaction of ruthenium bipyridine complex and oxidized glutathione on closed bipolar electrode array" at 72nd Annual ISE Meeting.
Seminar for the 1st grade student have started. We will make a glucose sensor with Mr. Kani and Ms. Yonemoto from the Department of Applied Chemistry.
An article entitled “Detection and 2D imaging of dopamine distribution using a closed bipolar electrode system by applying cathodic luminophore” of which K. Y. Inoue is one of a corresponding author is accepted for publication on ChemElectroChem.
K. Y. Inoue made a lecture on "Ultra-sensitive current detection type CMOS bioimaging sensor Bio-LSI" at 33rd Symposium of Multimodal Bioimageing Sensor Association.
An article entitled “Electrochemical sensor to detect proteinuria using peptidases and glutamate oxidase jointly immobilized on a Prussian blue-modified electrode”of which K. Y. Inoue is one of a corresponding author is accepted for publication on Electrochemistry.
A review of "Development of Biosensors Using Bipolar Electrode" by K. Y. Inoue was published on Monthly Bioindustry(CMC Publishing) 38(5),57-67,2021 (Japanese)
The spring semester has begun. K. Y. Inoue teaches first-year Basic Chemistry (Monday, 4th period), second-year Chemistry Laboratory (Thursday, 3rd–5th periods), and the latter half of first-year Basic Analytical Chemistry (Tuesday, 1st period).
The new academic year has begun, and Naganuma joined the laboratory as a fourth-year undergraduate student to conduct his graduation research.
Our website has been released.

This website was created under the guidance of Assist. Prof. M. Takahashi . I would like to thank Prof. Takahashi for his guidance and kind understanding to use the format of his website.
K. Y. Inoue introduced our technologies on biosensors and bioimaging systems based on electrochemistry at 2020FY 1st Meeting of New Technology Information Club of University of Ymanashi.
K. Y. Inoue gave an invited lecture on biosensing and bioimaging devices using closed bipolar electrode at 30th Annual Meeting of MRS-J.
Special feature of "Biosensors and biosensing in the era of digital health" that K. Y. Inoue mainly edited was published on Electrochemistry Vol.88 No.4.
R. Naganuma joined lab as an B3 student
K. Y. Inoue presented research results on principle verification of electrochemical imaging using bipolar electrode array at The 66th Annual Meeting of Polarographic Society of Japan.
K. Y. Inoue gave an invited lecture on closed bipolar electrochemistry for sensor and bioimaging applications at PRiME 2020.
K. Y. Inoue gave an invited lecture on daily unobtrusive sensing and health monitoring by biosensors at The 20th Annual Meeting of the Japanese Society of Anti-Aging Medicine.
Lab Started

Contact Information

4-3-11, Takeda, Kofu, 400-8511, Japan
Center for Basic Education, Faculty of Engineering, Graduate Faculty of Interdisciplinary Research, University of Yamanashi
K. Y. Inoue Group
E-mail: inokumi[at]yamanashi.ac.jp

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